By Simon Fillatreau,Anne O'Garra
This quantity presents a suite of studies devoted to the biology of Interleukin (IL)-10. It comprises chapters on its significance for conserving immune homeostasis in people, its function in intestinal immunity and its features in the course of viral and bacterial infections. additionally, it provides experiences at the mechanisms linking innate microbial acceptance to the creation of IL-10 and on how IL-10 popularity through its receptor features. the jobs of T and B cells as proper assets of IL-10 also are mentioned, with an emphasis at the medical possibilities provided by means of IL-10-producing Tr1 cells for the suppression of undesirable immunity. eventually, the features of alternative cytokines of the IL-10 relatives are awarded. jointly, those articles supply a finished evaluation of our present wisdom on probably the most vital anti inflammatory cytokines recognized to date.
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Interleukin-10 in Health and Disease (Current Topics in Microbiology and Immunology) by Simon Fillatreau,Anne O'Garra